Oxalyl chloride → (3,5-Dimethylphenyl)acetyl chloride

HRID 1858070

Reaction equation

HRID 1858070 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([CH3:8])[CH:7]=1.C(Cl)(=O)C([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([Cl:16])=[O:12])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 47494952-(3,5-Dimethylphenyl)acetic acid

Product 1

HCID 15895699(3,5-Dimethylphenyl)acetyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of (3,5-dimethylphenyl)acetic acid (2.32 g in 25 mL dry methylene chloride) at 0° C. was added 0.055 mL N,N-dimethylformamide followed by the dropwise addition of 1.3 mL of oxalyl chloride. After 15 minutes the mixture was warmed to room temperature and stiffed for an additional 2 hours. Removal of the solvents in vacuo provided the title compound which was used without purification.

Workup

  1. customRemoval of the solvents in vacuo

Sources & evidence

ORD record
ord-8c608f1a92db4bf68265cc29748e2e21
Source dataset
uspto-grants-2000_11
Patent number
US06150352

Linked notes

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