Aminoacetaldehyde dimethyl acetal → N-(2,2-dimethoxyethyl)-2-Pyrazinamine
Reaction equation
Cl[CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.[CH3:8][O:9][CH:10]([O:13][CH3:14])[CH2:11][NH2:12]>C(N(CC)CC)C>[CH3:8][O:9][CH:10]([O:13][CH3:14])[CH2:11][NH:12][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-chloropiperazine (1.0 g in 5 mL dry toluene) was added 2,2-dimethoxyethylamine (1.1 g) followed by 1.2 mL triethylamine and the mixture heated to reflux on an oil bath. After 48 hours, the reaction mixture was applied to a flash chromatography column (silica gel) for purification (ethyl acetate:hexane, 7:3; then 100:0) to give the title compound (101 mg).
Workup
- temperaturethe mixture heated
- temperatureto reflux on an oil bath
- customthe reaction mixture was applied to a flash chromatography column (silica gel) for purification (ethyl acetate
Sources & evidence
- ORD record
- ord-389d8374effb4091bb62673d23d79bf4
- Source dataset
- uspto-grants-2000_11
- Patent number
- US06150352
Reaction notes
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