(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal → Glucose Monohydrate

HRID 1881348Notes

Reaction equation

CCCCC[C@H](O)/C=C/[C@@H]1[C@H]2C/C(/O[C@H]2C[C@H]1O)=C/CCCC(O)=[O:21].[O:26]=[CH:27][C@@H:28]([C@H:30]([C@@H:32]([C@@H:34]([CH2:36][OH:37])[OH:35])[OH:33])[OH:31])[OH:29]>>[CH2:36]([OH:37])[C@@H:34]([OH:35])[C@@H:32]([OH:33])[C@H:30]([OH:31])[C@@H:28]([OH:29])[CH:27]=[O:26].[OH2:21]

Participants

Reactant 2

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

HCID 5282411Prostacyclin

Product 1

HCID 22814120Glucose Monohydrate

Procedure

The epoprostenol degraded in 5% Dextrose solution (D5W) more than in the saline. The 6-keto PGF levels were very low, yet no other peaks were observed. Here, approximately 84% of the drug degraded after 8 hours, but no other peaks were detected as a degradation product.

Sources & evidence

ORD record: ord-7048a6a08ad5474c973889408ef033c0
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08318802B2

Reaction notes

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