Tetrahydrofuran → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrile

Reaction equation

CN.CO.[CH2:5]([N:7](CC)CC)C.O1CCCC1.Cl[C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1>O>[CH3:5][NH:7][C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 131141834-Chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile

HCID 57454252Monomethylamine methanol

Product 1

HCID 106789344-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrileYield 92%

Reagents, catalysts & solvents 1

Procedure

3 ml of a methylamine-methanol solution, and 246 mg of triethylamine were added to a tetrahydrofuran (10 mL) solution containing 150 mg of 4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile, and the mixture was stirred for 30 minutes at room temperature. After adding water, the solution was extracted with ethyl acetate, and dried with anhydrous magnesium sulfate. After concentration, 134 mg of a white solid was obtained as a subject compound.