Ethanol → 2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

HRID 1893404

Reaction equation

HRID 1893404 reaction equation
F[C:2](F)(F)[C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1.Br[CH2:15]C(=O)CC.C(O)C>[Pt](=O)=O.CO>[CH2:2]([C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1)[CH3:15]

Participants

6

Reactant 3

HCID 702EthanolHCID 131561-Bromo-2-butanoneHCID 147199282-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine2×

Product 1

HCID 147199292-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was prepared in an analogous manner to that described above for 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (Intermediate 4) but starting from 1-bromo-2-butanone instead of 3-bromo-1,1,1-trifluoro-2-propanone and using platinum (IV) oxide and ethanol in the place of 10% palladium on carbon paste and methanol for the hydrogenation step.

Sources & evidence

ORD record
ord-dc83d8cd0490483da8ea4fa3c7072d4e
Source dataset
uspto-grants-2013_08
Patent number
US08513248B2

Linked notes

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