p-Toluenesulfonic acid → 2,6-Difluoro-4-iodoaniline

HRID 189472

Reaction equation

HRID 189472 reaction equation
[F:1][c:2]1[c:3]([NH2:4])[c:5]([F:9])[cH:6][cH:7][cH:8]1.[I:21][N:22]1[C:23](=[O:24])[CH2:25][CH2:26][C:27]1=[O:28].[O:29]=[CH:30][N:31]([CH3:32])[CH3:33].[c:10]1([CH3:11])[cH:12][cH:13][c:14]([S:15]([OH:16])(=[O:17])=[O:18])[cH:19][cH:20]1>>[F:1][c:2]1[c:3]([NH2:4])[c:5]([F:9])[cH:6][c:7]([I:21])[cH:8]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 6228DimethylformamideHCID 796472,6-DifluoroanilineHCID 120273N-Iodosuccinimide

Product 1

HCID 2789432,6-Difluoro-4-iodoaniline

Sources & evidence

ORD record
ord-8dc329cd5b9d4255a3495f27b74bea58
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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