Hydrogen Peroxide → 2-Bromo-5-fluoropyridine 1-oxide
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=1.FC(F)(F)C(O)=[O:12].OO>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N+:3]=1[O-:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Bromo-5-fluoropyridine (15 g, 85.6 mmol), trifluoroacetic acid (70 mL, 908 mmol) and hydrogen peroxide (35% in water) (9 mL, 105 mmol) were stirred overnight at 70° C. The mixture was poured into water and extracted with dichloromethane. The organic layers were washed with NaHCO3 (aq), dried over MgSO4 and the solvent was removed i.vac.
Workup
- extractionextracted with dichloromethane
- washThe organic layers were washed with NaHCO3 (aq)
- dry with materialdried over MgSO4
- customthe solvent was removed i.vac
Sources & evidence
- ORD record
- ord-bbe4fada2d864a138ac62051dc94f10b
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08598190B2
Reaction notes
Loading…