Water → 1-Cbz-3-Boc-Amino pyrrolidine

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][NH:11][CH2:12][CH2:13]1.[CH2:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[O:28][C:29](=[O:30])[Cl:31].[CH2:33]([Cl:34])[Cl:35].[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[OH2:32]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][N:11]([C:29]([O:28][CH2:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)=[O:30])[CH2:12][CH2:13]1

Participants

Reactant 5

HCID 962Water

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 10387Benzyl chloroformate

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamate

Product 1

HCID 145554781-Cbz-3-Boc-Amino pyrrolidine

Sources & evidence

ORD record: ord-9c34d1ff92504255baaac517adf48d1f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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