3,5-Diamino-1,2,4-triazole → HCID 178508251, compound

HRID 1915597Notes

Reaction equation

HRID 1915597 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[NH:4][N:3]=1.[C:8]1([CH:14]([C:20](OCC)=[O:21])[C:15](OCC)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(N(CCCC)CCCC)CCC>[NH2:1][C:2]1[N:6]=[C:5]2[N:7]=[C:15]([OH:16])[C:14]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:20]([OH:21])[N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 150783,5-Diamino-1,2,4-triazoleHCID 66514Diethyl phenylmalonate

Product 1

HCID 178508251HCID 178508251, compound

Reagents, catalysts & solvents 1

HCID 7622TributylamineSolvent

Procedure

A solution of 9.0 g 3,5-diamino-1,2,4-triazole and 22.4 ml diethyl phenylmalonate in N,N-dibutylbutan-1-amine is heated under microwave irradiation to 180° C. for 8 h. The reaction mixture forms two layers after cooling to room temperature. The top layer is removed and the solvent of the lower layer is evaporated. The residue is treated with water and acidified with 5N HCl. The precipitated product is collected by filtration and dried. The crude product is used without further purification.

Workup

  1. customThe top layer is removed
  2. customthe solvent of the lower layer is evaporated
  3. additionThe residue is treated with water
  4. filtrationThe precipitated product is collected by filtration
  5. customdried
  6. customThe crude product is used without further purification

Sources & evidence

ORD record
ord-0264d4253e5240c2aa2fede970219094
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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