Hydrochloric Acid → HCID 40427065, compound
Reaction equation
[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].Cl>C(O)C.O=[Pt]=O>[NH2:1][C@@H:2]([CH2:6][CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[C:3]([OH:5])=[O:4]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of (2S)-2-amino-3-(pyridin-4-yl)propanoic acid LXXIII (660 mg, 4.0 mmol) in ethanol (120 mL) was added 1 N HCl (10 mL) and PtO2 (150 mg). The mixture was vigorously shaken 70 psi H2 in a Parr apparatus for 48 h. The mixture was filtered through Celite and the filtrate was concentrated to dryness giving crude (2S)-2-amino-3-(piperidin-4-yl)propanoic acid LXXIV as the hydrochloride salt (988 mg). ESIMS found for C8H16NO2 m/z 172.0 (M+).
Workup
- customfor 48 h
- filtrationThe mixture was filtered through Celite
- concentrationthe filtrate was concentrated to dryness
Sources & evidence
- ORD record
- ord-84ec602eb2424276bde373477954dd28
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178490B2
Reaction notes
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