Methylamine → 1-(Methylamino)cyclopentane-1-carbonitrile
Reaction equation
[CH3:1][NH2:2].[C:3]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4]1.C[Si]([C:13]#[N:14])(C)C>>[CH3:1][NH:2][C:3]1([C:13]#[N:14])[CH2:7][CH2:6][CH2:5][CH2:4]1Participants
4
Procedure
Methylamine was bubbled into a refrigerated mixture of cyclopentanone (0.252 g, 3 mmol) and trimethylsilyl cyanide (0.396 g, 4 mmol) until the volume doubled. The mixture was stirred 3 h and then concentrated to dryness to obtain 31a (0.372 g, quantitative).
Workup
- concentrationconcentrated to dryness
Sources & evidence
- ORD record
- ord-cf3bcd57cdc245af8b43b0f50920a195
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08183274B2
Reaction notes
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