Trichloroacetyl chloride → 2,2,2-Trichloro-1-morpholin-4-ylethanone
Reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[Cl:13][C:14]([Cl:19])([Cl:18])[C:15](Cl)=[O:16]>CCOC(C)=O>[Cl:13][C:14]([Cl:19])([Cl:18])[C:15]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:16]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Morpholine (4.0 mL, 45 mmol) is dissolved in EtOAc (50 mL) and saturated K2CO3 (40 mL) added. The mixture is cooled in an ice bath and trichloroacetyl chloride (5.0 mL, 45 mmol) added drop-wise. The reaction is stirred for 20 min then diluted with EtOAc (200 mL) and washed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL). The organic layer is dried over MgSO4. Rotary evaporation gives trichloroacetylmorpholine.
Workup
- temperatureThe mixture is cooled in an ice bath
- washwashed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL)
- dry with materialThe organic layer is dried over MgSO4
- customRotary evaporation
Sources & evidence
- ORD record
- ord-5b24642c9cda4212a92327a9f47a5809
- Source dataset
- uspto-grants-1997_12
- Patent number
- US05703075
Reaction notes
Loading…