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Methylamine → HCID 67153355, compound

HRID 1949309
Notes
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Reaction equation

HRID 1949309 reaction equation
CS(OCCCOC1C=CC=C(C2N(C3C=CC=C(Cl)C=3)N=C(C(N3CC(=O)NC3)=O)C=2)C=1)(=O)=O.CN.[CH:38]([OH:40])=[O:39].[Cl:41][C:42]1[CH:43]=[C:44]([N:48]2[C:52]([C:53]3[CH:58]=[CH:57][CH:56]=[C:55]([O:59][CH2:60][CH2:61][CH2:62][N:63](C)[CH3:64])[CH:54]=3)=[CH:51][C:50]([C:66]([N:68]3[CH2:72][C:71](=[O:73])[NH:70][CH2:69]3)=[O:67])=[N:49]2)[CH:45]=[CH:46][CH:47]=1>O1CCCC1>[CH:38]([OH:40])=[O:39].[Cl:41][C:42]1[CH:43]=[C:44]([N:48]2[C:52]([C:53]3[CH:58]=[CH:57][CH:56]=[C:55]([O:59][CH2:60][CH2:61][CH2:62][NH:63][CH3:64])[CH:54]=3)=[CH:51][C:50]([C:66]([N:68]3[CH2:72][C:71](=[O:73])[NH:70][CH2:69]3)=[O:67])=[N:49]2)[CH:45]=[CH:46][CH:47]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 6329MethylamineHCID 58277334HCID 58277334, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153355HCID 67153355, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 120A and methylamine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 46 mg (44% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-fb01f86e278d4cb08eea18ee8d605b1e
Source dataset
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08399682B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes