Dimethylformamide → 4,6-dichloro-N-methyl-N-(prop-2-yn-1-yl)pyrimidine-5-carboxamide

Reaction equation

[CH3:16][NH:17][CH2:18][C:19]#[CH:20].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([Cl:11])[c:7]1[C:8](=[O:9])[OH:10].[Cl:28][CH2:29][Cl:30].[O:31]=[CH:32][N:33]([CH3:34])[CH3:35].[S:12]([Cl:13])([Cl:14])=[O:15]>>[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([Cl:11])[c:7]1[C:8](=[O:10])[N:17]([CH3:16])[CH2:18][C:19]#[CH:20]

Participants

Reactant 6

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 24386Thionyl Chloride

HCID 96160N-methylpropyn-2-ylamine

HCID 248204874,6-Dichloropyrimidine-5-carboxylic acid

Product 1

HCID 121631394,6-dichloro-N-methyl-N-(prop-2-yn-1-yl)pyrimidine-5-carboxamide

Sources & evidence

ORD record: ord-5eec0bd2af9e43bdb176aebeccd6ef33
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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