Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride
Reaction equation
[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5](O)=[O:6])[CH2:3]1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C=O)C>[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5]([Cl:14])=[O:6])[CH2:3]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.
Workup
- customThe solvent was then evaporated
Sources & evidence
- ORD record
- ord-e2dfe99002a7405ab1ccb963ff74ebaf
- Source dataset
- uspto-grants-2000_09
- Patent number
- US06121281
Reaction notes
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