4-(Dimethylamino)pyridine → 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy)phenyl)urea

HRID 196359

Reaction equation

HRID 196359 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][n:7](-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[c:8]([NH:10][C:11]([O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)=[O:19])[cH:9]1.[CH3:26][O:27][c:28]1[cH:29][c:30]2[c:31]([O:43][c:44]3[cH:45][c:46]([NH2:47])[cH:48][cH:49][cH:50]3)[n:32][cH:33][n:34][c:35]2[cH:36][c:37]1[O:38][CH2:39][CH2:40][O:41][CH3:42].[CH3:60][N:61]([c:62]1[cH:63][cH:64][n:65][cH:66][cH:67]1)[CH3:68].[CH:51]([N:52]([CH:53]([CH3:54])[CH3:55])[CH2:56][CH3:57])([CH3:58])[CH3:59]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][n:7](-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[c:8]([NH:10][C:11](=[O:19])[NH:47][c:46]2[cH:45][c:44]([O:43][c:31]3[c:30]4[cH:29][c:28]([O:27][CH3:26])[c:37]([O:38][CH2:39][CH2:40][O:41][CH3:42])[cH:36][c:35]4[n:34][cH:33][n:32]3)[cH:50][cH:49][cH:48]2)[cH:9]1

Participants

5

Reactant 4

HCID 142844-(Dimethylamino)pyridineHCID 81531DiisopropylethylamineHCID 46196894phenyl 3-tert-butyl-1-phenyl-1H-pyrazol-5-ylcarbamateHCID 668758053-(6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy)aniline

Product 1

HCID 582677791-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-0a06fa4ec4a6492dbe6ec778e4668f9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…