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Hydrochloric Acid → 2-{2-[5-(4-Methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-1-(2,2,2-trifluoro-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride

HRID 1968562
Notes
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Reaction equation

HRID 1968562 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14]([CH2:42][C:43]([F:46])([F:45])[F:44])[C:15]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]4[CH:29]=[C:28]([N:30]5[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]5)[CH:27]=[CH:26][C:25]=4[O:37][C:38]([F:41])([F:40])[F:39])[N:18]=3)=[CH:16][C:10]=2[C:9]1=[O:47])=O)(C)(C)C.[ClH:48]>O1CCCC1.O1CCOCC1>[ClH:48].[CH3:36][N:33]1[CH2:32][CH2:31][N:30]([C:28]2[CH:27]=[CH:26][C:25]([O:37][C:38]([F:41])([F:39])[F:40])=[C:24]([NH:23][C:19]3[N:18]=[C:17]([C:15]4[N:14]([CH2:42][C:43]([F:45])([F:46])[F:44])[C:11]5[CH2:12][CH2:13][NH:8][C:9](=[O:47])[C:10]=5[CH:16]=4)[CH:22]=[CH:21][N:20]=3)[CH:29]=2)[CH2:35][CH2:34]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 866651452-{2-[5-(4-Methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-4-oxo-1-(2,2,2-trifluoro-ethyl)-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

Product 1

HCID 866651462-{2-[5-(4-Methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-1-(2,2,2-trifluoro-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochlorideYield 98%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent
HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-{2-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-4-oxo-1-(2,2,2-trifluoro-ethyl)-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (25 mg, 0.037 mmol) in tetrahydrofuran (1 mL), 4M HCl in dioxane (0.4 mL) were added. The solution was stirred at room temperature over night. The solvent was evaporated under vacuo to yield 22 mg (98%) of the title compound as a beige powder.

Workup

  1. customThe solvent was evaporated under vacuo

Sources & evidence

ORD record
ord-82bd291e010b4bc1b04b96612be88be4
Source dataset
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08426417B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes