Sodium Bicarbonate → 3-Cyclopropylthiomorpholine 1,1-dioxide
Reaction equation
Cl.[CH:2]1([CH:5]2[CH2:10][S:9](=[O:12])(=[O:11])[CH2:8][CH2:7][NH:6]2)[CH2:4][CH2:3]1.C([O-])(O)=O.[Na+]>CCOC(C)=O>[CH:2]1([CH:5]2[CH2:10][S:9](=[O:11])(=[O:12])[CH2:8][CH2:7][NH:6]2)[CH2:4][CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 100 mL round-bottomed flask was charged with 3-cyclopropylthiomorpholine 1,1-dioxide hydrochloride (1.00 g, 4.72 mmol) and 10 mL of EtOAc. To this was added 15 mL of saturated aqueous NaHCO3. After stirring at room temperature for 15 min, the layers were separated. The organics were dried (MgSO4), filtered, and concentrated to give 3-cyclopropylthiomorpholine 1,1-dioxide (0.800 g) as a colorless oil.
Workup
- customthe layers were separated
- dry with materialThe organics were dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-7149c6430c64448da0520be0a75968d2
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08431563B2
Reaction notes
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