3,4-Dichlorobenzyl chloride → 4-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one
Reaction equation
[CH3:1][C:2]1[C:6](=[O:7])[N:5]=[N:4][CH:3]=1.[H-].[Na+].[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14]Cl>CN(C)C=O>[CH3:1][C:2]1[C:6](=[O:7])[N:5]([CH2:14][C:13]2[CH:16]=[CH:17][C:18]([Cl:19])=[C:11]([Cl:10])[CH:12]=2)[NH:4][CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
19.6 g of 4-methylpyrazol-5-one were added in portions to a suspension of 5.0 g of sodium hydride in 100 ml of absolute dimethylformamide. After the evolution of H2 had ceased, 39 g of 3,4-dichlorobenzyl chloride were added dropwise to the reaction solution.
Sources & evidence
- ORD record
- ord-aecfa31f668944d89b40b6511cf9f4d3
- Source dataset
- uspto-grants-1976_12
- Patent number
- US04000294
Reaction notes
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