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Diphosgene → HCID 21201246, compound

HRID 1978858
Notes
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Reaction equation

HRID 1978858 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH:9]1[O:13][CH2:12][CH2:11][O:10]1.Cl[C:15](OC(Cl)(Cl)Cl)=[O:16]>C(OCC)(=O)C.C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]=[C:15]=[O:16])=[CH:4][C:3]=1[CH:9]1[O:10][CH2:11][CH2:12][O:13]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 10426DiphosgeneHCID 144962994-Chloro-3-(1,3-dioxolan-2-yl)aniline

Product 1

HCID 21201246HCID 21201246, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
22.5 °C

Procedure

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

2.0 g of 4-chloro-3-(1,3-dioxolan-2-yl)-aniline in 25 ml of ethyl acetate were added to a solution of 3.0 g of trichloromethyl chloroformate in 50 ml of toluene at about 20-25° C. This mixture was stirred for 2 hours at 20-25° C. and then for a further 5 hours at the reflux temperature. Thereafter, the reaction mixture was evaporated down and the residue was dried under greatly reduced pressure.

Workup

  1. waitfor a further 5 hours at the reflux temperature
  2. customThereafter, the reaction mixture was evaporated down
  3. customthe residue was dried under greatly reduced pressure

Sources & evidence

ORD record
ord-d214111a7ab24df6b7c784f47ea44d49
Source dataset
uspto-grants-2001_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06239074B1

Reaction notes

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