Hydrochloric Acid → 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

HRID 1981166Notes

Reaction equation

HRID 1981166 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:6][CH:5]=1.C(OC(C)C)(C)C>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 130540183,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole

Product 1

HCID 201515453,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2.9 ml of a solution of 5.9N hydrogen chloride in ethanol were added to a solution of 5 g of the product of Example 1, in 5 ml of ethanol and the mixture was stirred while adding isopropyl ether thereto. The mixture was stirred for 24 hours and was filtered. The product was empasted with isopropyl ether, filtered and dried under pressure to obtain 4.4 g of 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride.

Workup

  1. stirringThe mixture was stirred for 24 hours
  2. filtrationwas filtered
  3. filtrationfiltered
  4. customdried under pressure

Sources & evidence

ORD record
ord-c8be1148941a4630b76766718056bdad
Source dataset
uspto-grants-1985_04
Patent number
US04512997

Reaction notes

Loading…