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Water → ([3-(pentafluoroethyl)-1H-pyrazole-1-yl]methyl}(3,3, 3-trifluoropropyl)malononitrile

HRID 1982981
Notes
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Reaction equation

HRID 1982981 reaction equation
Cl[CH2:2][N:3]1[CH:7]=[CH:6][C:5]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])=[N:4]1.[F:15][C:16]([F:25])([F:24])[CH2:17][CH2:18][CH:19]([C:22]#[N:23])[C:20]#[N:21].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:13][C:8]([F:14])([C:5]1[CH:6]=[CH:7][N:3]([CH2:2][C:19]([CH2:18][CH2:17][C:16]([F:15])([F:24])[F:25])([C:20]#[N:21])[C:22]#[N:23])[N:4]=1)[C:9]([F:12])([F:11])[F:10]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 221857612-(3,3,3-Trifluoropropyl)malononitrileHCID 231491811-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

Product 1

HCID 86612667([3-(pentafluoroethyl)-1H-pyrazole-1-yl]methyl}(3,3, 3-trifluoropropyl)malononitrileYield 42.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.01 g of 1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole and 1.39 g of (3,3,3-trifluoropropyl)malononitrile were dissolved in 25 ml of N,N-dimethylformamide. 2.38 g of potassium carbonate was added to the solution under ice cooling with stirring, followed by stirring at room temperature for overnight. Water was added to the reaction mixture, and then extracted with MTBE. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.31 g of {[3-(pentafluoroethyl)-1H-pyrazole-1-yl]methyl}(3,3, 3-trifluoropropyl)malononitrile (referred as the compound of the present invention (36), hereinafter) shown by below formula.

Workup

  1. stirringby stirring at room temperature for overnight
  2. extractionextracted with MTBE
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-cfad6400a20d4338a3092f77ab86e829
Source dataset
uspto-grants-2009_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07541374B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes