Hydrochloric Acid → HCID 58934102, compound

1.2 g lithium aluminum hydride were dissolved in 100 ml dry tetrahydro-furan. 5.3 g 4-Butyl-2-(4-trifluormethyl-phenyl)-thiazol-5- carboxylic acid methyl ester, dissolved in 100 ml tetrahydro-furan, were added. The reaction mixture was stirred at room temperature over a period of one hour, then 50 ml saturated ammonium chloride solution and 50 ml of a 1 molar hydrochloric acid solution was added. The reaction mixture was extracted five times with portions of 60 ml of ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent removed under reduced pressure to provide 4.6 g [4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-yl]-methanol as a yellow oil , which solidified upon standing at room temperature.

1. additionwere added
2. extractionThe reaction mixture was extracted five times with portions of 60 ml of ethyl acetate
3. dry with materialThe combined organic layers were dried over MgSO4
4. customthe solvent removed under reduced pressure

ORD record

ord-cab93090d6b541f8abad2703e3ca2e05

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07541464B2