Tetrahydrofuran → N-(6-(6-(3-methoxyphenoxy)pyrimidin-4-ylamino)pyridine-2-yl)acrylamide

HRID 198394

Reaction equation

HRID 198394 reaction equation
[C:24]([CH:25]=[CH2:26])(=[O:27])[Cl:28].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:34][N:35]1[CH2:36][CH2:37][CH2:38][C:39]1=[O:40].[O:1]([CH3:2])[c:3]1[cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][c:14]3[n:15][c:16]([NH2:20])[cH:17][cH:18][cH:19]3)[n:10][cH:11][n:12]2)[cH:21][cH:22][cH:23]1>>[O:1]([CH3:2])[c:3]1[cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][c:14]3[n:15][c:16]([NH:20][C:24]([CH:25]=[CH2:26])=[O:27])[cH:17][cH:18][cH:19]3)[n:10][cH:11][n:12]2)[cH:21][cH:22][cH:23]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13140Acryloyl chlorideHCID 13387N-methyl-2-pyrrolidoneHCID 57708231N2-(6-(3-methoxylphenoxy)pyrimidin-4-yl)pyridine-2,6-diamine

Product 1

HCID 42601817N-(6-(6-(3-methoxyphenoxy)pyrimidin-4-ylamino)pyridine-2-yl)acrylamide

Sources & evidence

ORD record
ord-660d6bf96b174a5f804a1cea2baf0c3f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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