Hydrochloric Acid → HCID 20402705, compound
Reaction equation
[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:21])[CH2:18][NH:19][OH:20])=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:22]>C(O)(C)C>[Cl-:22].[OH:20][N:19]1[CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]2=[C:13]([CH3:14])[N:12]([CH3:15])[CH:11]=[C:10]2[NH2+:16][C:17](=[O:21])[CH2:18]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
The compound of example 1 (79.4 g) was suspended in isopropanol containing 2.1% of HCl (3700 ml) and refluxed for 2 hours with stirring. The reaction mixture was then cooled to 0° C. and a first crop (61 g) of the compound of the title which crystallized out was recovered by filtration. A second crop (9 g) was obtained by concentrating the mother liquors to a small volume. M.p. 220°-223° C. with decomposition.