Hydrochloric Acid → 6-Amino-6-desoxy-L-sorbose hydrochloride

HRID 1995723

Reaction equation

HRID 1995723 reaction equation
C(OC([NH:8][CH2:9][C@H:10]([OH:19])[C@@H:11]([OH:18])[C@H:12]([OH:17])[C:13](=[O:16])[CH2:14][OH:15])=O)(C)(C)C.O.[ClH:21]>C(O)CC>[ClH:21].[NH2:8][CH2:9][C@H:10]([OH:19])[C@@H:11]([OH:18])[C@H:12]([OH:17])[C:13](=[O:16])[CH2:14][OH:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 22824282HCID 22824282, compound

Product 1

HCID 867390326-Amino-6-desoxy-L-sorbose hydrochloride

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

20 g of N-tert.-butoxycarbonyl-6-amino-6-desoxy-L-sorbose were introduced in portions into a mixture of 6.4 ml of H2O and 13.2 ml of concentrated hydrochloric acid, whilst stirring and cooling. The batch was subsequently stirred for 2 hours, without cooling, and 120 ml of n-propanol were then added in the course of 2 hours. The resulting suspension of crystals was then stirred at 0° C. for 1 hour and filtered on a suction filter. The crystals were washed with a little n-propanol and dried at room temperature in a vacuum drying cabinet.

Workup

  1. temperaturecooling
  2. stirringThe batch was subsequently stirred for 2 hours
  3. temperaturewithout cooling
  4. additionThe resulting suspension of crystals
  5. stirringwas then stirred at 0° C. for 1 hour
  6. filtrationfiltered on a suction
  7. filtrationfilter
  8. washThe crystals were washed with a little n-propanol
  9. customdried at room temperature in a vacuum
  10. customdrying cabinet

Sources & evidence

ORD record
ord-3826130eb10d4efd94c6a5428627b6f6
Source dataset
uspto-grants-1983_09
Patent number
US04405714

Linked notes

Loading…