Dimethyl Sulfate → 5-bromo-7-fluoro-1-methyl-1H-indazole

HRID 1996237

Reaction equation

HRID 1996237 reaction equation

[CH3:1]OS(OC)(=O)=O.[F:2][c:3]1[c:12]([c:8]2[cH:7][c:5]([Br:6])[cH:4]1)[nH:11][n:10][cH:9]2>>[CH3:1][n:11]1[c:12]([c:8]2[cH:9][n:10]1)[c:3]([F:2])[cH:4][c:5]([Br:6])[cH:7]2

Participants

6

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 667931105-Bromo-7-fluoro-1H-indazole

Product 1

HCID 840568825-bromo-7-fluoro-1-methyl-1H-indazole

Reagents, catalysts & solvents 3

HCID 101955ChloroisopropylmagnesiumReagent

HCID 6228DimethylformamideSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 25 °C

Sources & evidence

ORD record: ord-8c6e1a309e834a0f8daed429b57e01a4
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Linked notes

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