Methanol → Methyl 3-oxocyclopent-1-enecarboxylate

HRID 2001548

Reaction equation

HRID 2001548 reaction equation
[O:1]=CN1S(=O)(=O)[c:8]([c:4]2[C:2]1=[O:3])[cH:7]c[cH:6][cH:5]2.[CH3:9][OH:10].Cc1ccc(S(OC(CCC2=O)=C2)(=O)=O)cc1>>[CH3:9][O:10][C:2]([C:4]([CH2:8][CH2:7][C:6]1=[O:1])=[CH:5]1)=[O:3]

Participants

8

Reactant 3

HCID 887MethanolHCID 546716891,1,3-Trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazole-2-carbaldehydeHCID 86196686(3-Oxocyclopenten-1-yl) 4-methylbenzenesulfonate

Product 1

HCID 11029917Methyl 3-oxocyclopent-1-enecarboxylate

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 887MethanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-26eaaca199544c9189456df8759807a8
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Linked notes

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