Tetrahydrofuran → [3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amine

Reaction equation

[Al+3:23].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24].[nH:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][c:8]([CH:10]([CH2:11][C:12](=[O:13])[NH:14][CH3:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:9]12>>[nH:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][c:8]([CH:10]([CH2:11][CH2:12][NH:14][CH3:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:9]12

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium Cation

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 598317453-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide

Product 1

HCID 17747555[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amine

Sources & evidence

ORD record: ord-d369d1b2c5ba4ae4a7f7e5520e5e8d76
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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