Benzene, 1-ethoxy-2-iodo- → tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

HRID 2004415

Reaction equation

HRID 2004415 reaction equation
[CH3:1][CH2:2][O:3][c:4]1[c:9](I)[cH:8][cH:7][cH:6][cH:5]1.[CH3:10][C:11]([O:14][C:15]([N:17]1[CH2:23][C@H:21]([OH:22])[CH2:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])[CH3:12]>>[CH3:1][CH2:2][O:3][c:4]1[c:9]([O:22][C@H:21]2[CH2:23][N:17]([C:15]([O:14][C:11]([CH3:13])([CH3:12])[CH3:10])=[O:16])[CH2:18][CH2:19][CH2:20]2)[cH:8][cH:7][cH:6][cH:5]1

Participants

8

Reactant 2

HCID 136415Benzene, 1-ethoxy-2-iodo-HCID 1514398(R)-1-Boc-3-hydroxypiperidine

Product 1

HCID 131737068tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

Reagents, catalysts & solvents 5

HCID 23683543Potassium t-amylateReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 2733821trans-N,N'-dimethyl-1,2-cyclohexanediamineCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-9871f4adf0134ba78052fd37c68899b8
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Linked notes

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