(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acid → 4,4,4-Trifluoro-3-phenylbutanoic acid

HRID 2006961

Reaction equation

HRID 2006961 reaction equation

[OH:1][C:2](\[CH:4]=[C:5](\[C:12]([F:15])([F:14])[F:13])/[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)=[O:3]>>[OH:1][C:2]([CH2:4][CH:5]([C:12]([F:15])([F:14])[F:13])[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)=[O:3]

Participants

9

Reactant 1

HCID 2054639(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acid

Product 1

HCID 103760724,4,4-Trifluoro-3-phenylbutanoic acid

Reagents, catalysts & solvents 7

HCID 8083MorpholineReagent

HCID 11776TriphenylphosphineReagent

HCID 2734567(2S,4S)-2,4-Bis(diphenylphosphino)pentaneCatalyst

HCID 178420233HCID 178420233, compoundCatalyst

HCID 962WaterSolvent

HCID 71583Chloroform-DSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 25 °C

Sources & evidence

ORD record: ord-63a3cdb6ab364565b6d44728b75931dd
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Linked notes

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