1-Bromo-3-chloro-2-fluorobenzene → HCID 178461766, compound

HRID 2019043

Reaction equation

HRID 2019043 reaction equation
[F:1][c:2]1[c:8](Br)[cH:7][cH:6][cH:5][c:3]1[Cl:4].[CH3:9][CH:10](C(O[K])=O)[C:11]#[N:12]>>[CH3:9][C@H:10]([c:8]1[c:2]([F:1])[c:3]([Cl:4])[cH:5][cH:6][cH:7]1)[C:11]#[N:12]

Participants

8

Reactant 2

HCID 36857621-Bromo-3-chloro-2-fluorobenzeneHCID 178458021HCID 178458021, compound

Product 1

HCID 178461766HCID 178461766, compound

Reagents, catalysts & solvents 5

HCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)ReagentHCID 167845palladium(II) acetateCatalystHCID 16218202di-tert-butyl[5-(di-tert-butylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]phosphaneCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-c322f28fcc794754a364470b572d1754
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Linked notes

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