1-Bromo-3-chloro-2-fluorobenzene → HCID 178461766, compound

HRID 2019061

Reaction equation

HRID 2019061 reaction equation
[CH3:1][CH:2](C(O[K])=O)[C:3]#[N:4].[F:5][c:6]1[c:12](Br)[cH:11][cH:10][cH:9][c:7]1[Cl:8]>>[CH3:1][C@H:2]([c:12]1[c:6]([F:5])[c:7]([Cl:8])[cH:9][cH:10][cH:11]1)[C:3]#[N:4]

Participants

7

Reactant 2

HCID 36857621-Bromo-3-chloro-2-fluorobenzeneHCID 178458021HCID 178458021, compound

Product 1

HCID 178461766HCID 178461766, compound

Reagents, catalysts & solvents 4

HCID 167845palladium(II) acetateCatalystHCID 16218202di-tert-butyl[5-(di-tert-butylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]phosphaneCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-980f43adaeb54aed87e40d2cafcaf67d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Linked notes

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