Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol
Reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH2:12]Cc1ccccc1.[Na+].COCCO[AlH2-]OCCOC>>[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 25 °C
Sources & evidence
- ORD record
- ord-70840df1ba8c44259b29543e43306fc4
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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