Tetrahydrofuran → 4-Bromomethyl-3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazole

Reaction equation

[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33].[Cl:1][c:2]1[c:3](-[c:9]2[n:10][o:11][c:12]([CH:16]([CH3:17])[CH3:18])[c:13]2[CH2:14][OH:15])[c:4]([Cl:8])[cH:5][cH:6][cH:7]1.[P:19]([Br:20])([Br:21])[Br:22]>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][o:11][c:12]([CH:16]([CH3:17])[CH3:18])[c:13]2[CH2:14][Br:20])[c:4]([Cl:8])[cH:5][cH:6][cH:7]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8857Ethyl Acetate

HCID 24614Phosphorus tribromide

HCID 10850745(3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl)methanol

Product 1

HCID 669064404-Bromomethyl-3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazole

Sources & evidence

ORD record: ord-6b8cd0a353344ebba0cb4e50dc2fed75
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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