Dimethylformamide → (4-Hydroxy-3-methoxyphenyl)(spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-yl)methanone

HRID 203909

Reaction equation

HRID 203909 reaction equation
[CH2:50]1[O:51][CH2:52][CH2:53][O:54][CH2:55]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:42][CH2:43][Cl:44].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[OH:1][c:2]1[c:3]([O:11][CH3:12])[cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[S:13]([Cl:14])([Cl:15])=[O:16].[cH:17]1[cH:18][cH:19][c:20]2[n:21]1-[c:22]1[c:23]([cH:31][cH:32][cH:33][cH:34]1)[O:24][C:25]21[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1>>[OH:1][c:2]1[c:3]([O:11][CH3:12])[cH:4][c:5]([C:6](=[O:8])[N:28]2[CH2:27][CH2:26][C:25]3([c:20]4[cH:19][cH:18][cH:17][n:21]4-[c:22]4[c:23]([cH:31][cH:32][cH:33][cH:34]4)[O:24]3)[CH2:30][CH2:29]2)[cH:9][cH:10]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8468Vanillic AcidHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 312751,4-DioxaneHCID 58550727Spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]

Product 1

HCID 58551823(4-Hydroxy-3-methoxyphenyl)(spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-yl)methanone

Sources & evidence

ORD record
ord-7b4703572026400e8a7551c2e87c3fc0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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