3-azetidinecarboxylic Acid → 1-{5-[4-(2-Isopropyl-phenoxy)-benzylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carboxylic acid

HRID 2040113

Reaction equation

HRID 2040113 reaction equation
[CH:1]([C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[O:6][C:7]1[CH:21]=[CH:20][C:10]([CH:11]=[C:12]2[S:16][C:15](SC)=[N:14][C:13]2=[O:19])=[CH:9][CH:8]=1)([CH3:3])[CH3:2].[NH:26]1[CH2:29][CH:28]([C:30]([OH:32])=[O:31])[CH2:27]1>CN(C=O)C>[CH:1]([C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[O:6][C:7]1[CH:21]=[CH:20][C:10]([CH:11]=[C:12]2[S:16][C:15]([N:26]3[CH2:29][CH:28]([C:30]([OH:32])=[O:31])[CH2:27]3)=[N:14][C:13]2=[O:19])=[CH:9][CH:8]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 931923-azetidinecarboxylic AcidHCID 690899295-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one

Product 1

HCID 690903861-{5-[4-(2-Isopropyl-phenoxy)-benzylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

was prepared from 5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one and azetidine-3-carboxylic acid and substituting MeCN with DMF as described in Example 5C

Sources & evidence

ORD record
ord-0a181029bd3b42d4bbd01523928417cf
Source dataset
uspto-grants-2013_11
Patent number
US08580832B2

Linked notes

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