Potassium Carbonate → 2-Nitrosooctahydro-2H-pyrido[1,2-a]pyrazine
Reaction equation
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12.[N+:11]([O-])([O-])=[O:12].[Na+].C(=O)([O-])[O-].[K+].[K+]>Cl.O>[N:11]([N:6]1[CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]2[CH2:1]1)=[O:12]Participants
6
Procedure
Octahydropyrido-[1,2-a]-pyrazine (5 g) was dissolved in hydrochloric acid (5 N, 16 ml) and sodium nitrate (2.7 g) in water (10 ml) added dropwise at 0°. The solution was then heated at 60° for 30 minutes and stood at room temperature for 3 hours. It was basified, saturated with potassium carbonate and extracted with ether. The ethereal extract was dried and evaporated to give N-nitroso-octahydropyrido-[1,2-a]-pyrazine as an oil.
Workup
- temperatureThe solution was then heated at 60° for 30 minutes
- extractionextracted with ether
- extractionThe ethereal extract
- customwas dried
- customevaporated
Sources & evidence
- ORD record
- ord-efceddec38164246b24abb76587a7529
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04213983
Reaction notes
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