Ethyl Bromide → 65755-78-4
Reaction equation
[Na].[CH2:2](Br)[CH3:3].[CH:5]1([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>N>[CH2:2]([C:5]1([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium (3.7 g, 0.16 mole) was added to liquid ammonia (300 ml.) at 35° C. A catalytic amount of ferric nitrate was then added. After the solution had become grey in colour, ethyl bromide (17.4 g, 0.16 mole) and cyclooctyl cyanide (20.0 g, 0.14 mole) were added very slowly. The liquid ammonia was then allowed to evaporate over a period of 20 hours. Benzene and then water were added to the residue. The benzene layer was dried (MgSO4) and distilled to give 1-ethylcyclooctyl cyanide, bp. 130-132°/17 mm.
Workup
- additionwere added very slowly
- customto evaporate over a period of 20 hours
- additionBenzene and then water were added to the residue
- dry with materialThe benzene layer was dried (MgSO4)
- distillationdistilled
Sources & evidence
- ORD record
- ord-38fb0b9b164e4885bc09f3f4eb8454ba
- Source dataset
- uspto-grants-1982_03
- Patent number
- US04318900
Reaction notes
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