Hydrochloric Acid → Desflurane Hydrogen Fluoride

A 6-ft×2-inch tube was charged with chromia catalyst and isoflurane and 5 mole equivalents of HF were introduced in vapor form at a pressure of 150 psig. The by-product HCl, desflurane, unreacted isoflurane and unreacted HF that exited the tube were collected and distilled at 150 psig to remove HCl. After HCl was removed, the reaction mixture was heated at total reflux. At a pressure of 150 psig, the material collected overhead at 82° C. was the desflurane/hydrogen fluoride azeotrope. The composition of the azeotrope, after analysis was determined to be 85% desflurane and 15% HF, by weight. The table below shows the boiling point and composition of the azeotrope at different pressures.

1. additionwere introduced in vapor form at a pressure of 150 psig
2. customwere collected
3. distillationdistilled at 150 psig
4. customto remove HCl
5. customAfter HCl was removed
6. temperaturethe reaction mixture was heated at total reflux
7. customAt a pressure of 150 psig, the material collected overhead at 82° C.

ORD record

ord-9b362dfffe6f44bfaab447790b93a49e

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08283500B2