Potassium Carbonate → 5-(4-n-Pentylphenyl)-pyrazin-2-yl p-n-propylbenzyl ether

HRID 2072624

Reaction equation

HRID 2072624 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[CH:14][C:15]([OH:18])=[N:16][CH:17]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=1)[CH2:20][CH3:21].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][O:18][C:15]2[CH:14]=[N:13][C:12]([C:9]3[CH:8]=[CH:7][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:11][CH:10]=3)=[CH:17][N:16]=2)=[CH:24][CH:23]=1)[CH2:20][CH3:21]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 222468661-(Bromomethyl)-4-propylbenzeneHCID 178442096HCID 178442096, compound

Product 1

HCID 198596675-(4-n-Pentylphenyl)-pyrazin-2-yl p-n-propylbenzyl ether

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 10.4 g of 5-(4-pentylphenyl)-2-pyrazinol (obtainable analogously to Japanese Preliminary Published Application 144,770/84), 7.7 g of p-n-propylbenzyl bromide, 8.6 g of potassium carbonate and 50 ml of dimethylformamide is heated at 90° for 10 hours. Customary working up gives 5-(4-n-pentylphenyl)-pyrazin-2-yl p-n-propylbenzyl ether.

Workup

  1. temperatureis heated at 90° for 10 hours

Sources & evidence

ORD record
ord-7d68e957568f4517a17ac1cc117a670e
Source dataset
uspto-grants-1990_04
Patent number
US04913837

Linked notes

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