Methanol → HCID 58387985, compound
Reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][C:9]([Br:15])=[CH:8]2)=[O:4].O1CCCC1.CO.O.[OH-].[Li+:25]>O>[Li+:25].[Br:15][C:9]1[CH:10]=[N:11][C:12]2[C:7]([CH:8]=1)=[CH:6][C:5]([C:3]([O-:4])=[O:2])=[CH:14][CH:13]=2Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of 3-bromo-quinoline-6-carboxylic acid methyl ester described in Preparation Example 162 (26 mg, 0.098 mmol) and tetrahydrofuran (2 mL) were added methanol (0.2 mL), lithium hydroxide monohydrate (4.1 mg, 0.098 mmol) and water (0.2 mL), and the solution was stirred overnight at room temperature. The solvent was evaporated in vacuo, and the title compound (27 mg) was obtained.
Workup
- customThe solvent was evaporated in vacuo
Sources & evidence
- ORD record
- ord-69828af9848b4de789c5f318648cb106
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07932272B2
Reaction notes
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