Trifluoroacetic acid → HCID 22731318, compound

HRID 2085596

Reaction equation

HRID 2085596 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 227312731-(2-Bromo-phenyl)-heptan-1-ol

Product 1

HCID 22731318HCID 22731318, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following General Procedure J and using 1-(2-Bromo-phenyl)-heptan-1-ol (1.86 g, 6.9 mmol), anhydrous dichloromethane (5 mL), trifluoroacetic acid (2.5 mL, 32.5 mmol) and triethyl silane (5 mL, 31 mmol) followed by flash column chromatography, the title compound was obtained (0.4 g, 23%).

Sources & evidence

ORD record
ord-2704e5e660b648e283de9f673fb2f4a1
Source dataset
uspto-grants-2004_04
Patent number
US06720423B2

Linked notes

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