2-Methoxyethylamine → N-(2-methoxyethyl)methanesulfonamide
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>ClCCl>[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:14]([CH3:13])(=[O:16])=[O:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirring solution of 2-methoxyethylamine (0.58 ml) in dichloromethane (10 ml) was added triethylamine (1.0 ml) and methanesulphonyl chloride (0.51 ml). The mixture was stirred at room temperature overnight. The solvents were removed in vacuo to give a crude product which was purified by flash chromatography to give N-(2-Methoxy-ethyl)-methanesulfonamide (0.74 g).
Workup
- customThe solvents were removed in vacuo
- customto give a crude product which
- customwas purified by flash chromatography
Sources & evidence
- ORD record
- ord-5c533c63910049a7973a3ff144baf9cf
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08450315B2
Reaction notes
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