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Water → HCID 10201592, compound

HRID 2100339
Notes
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Reaction equation

HRID 2100339 reaction equation
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:6]([C:7](N2CCCCC2)=[O:8])=[CH:5][CH:4]=1.Cl[C:18]1[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][N:27]=2)[N:19]=1.C([N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])C.O.[CH3:40]N(C)C=O>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([CH:40]2[CH2:36][CH2:35][N:34]([C:18]3[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]4[CH:31]=[CH:30][N:29]=[CH:28][N:27]=4)[N:19]=3)[CH2:37][CH2:38]2)=[O:8])=[CH:15][CH:16]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 179544602-Chloro-3-methyl-6-(pyrimidin-4-YL)pyrimidin-4-oneHCID 17954461(4-Chlorobenzoyl)piperidine hydrochloride

Product 1

HCID 10201592HCID 10201592, compoundYield 92%

Procedure

A solution of (4-Chlorobenzoyl)piperidine hydrochloride (140 mg, 0.539 mmol), 2-chloro-3-methyl-6-(4-pyrimidyl)-pyrimidine-4-one (120 mg, 0.539 mmol) and triethylamine (0.188 ml, 1.35 mmol) in N,N-dimethylformamide(2 ml) was stirred at room temperature. After stirring for several hours, water was added to the reaction mixture. The precipitate was filtered, washed with water and dried to give the title compound (204 mg, 92%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-090bb8de16bd4757a2ac772d0678b732
Source dataset
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07572793B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes