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Water → HCID 59809683, compound

HRID 2114342
Notes
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Reaction equation

HRID 2114342 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:15][CH3:16])[CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[Cl:17][C:18]1[CH:19]=[C:20]([N:25]([CH3:30])[CH2:26][C:27]([OH:29])=O)[CH:21]=[CH:22][C:23]=1[Cl:24].C(N(CC)CC)C.O>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([N:15]([CH3:16])[C:27](=[O:29])[CH2:26][N:25]([C:20]2[CH:21]=[CH:22][C:23]([Cl:24])=[C:18]([Cl:17])[CH:19]=2)[CH3:30])[CH2:9][N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[CH:5]=[CH:6][CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 57418650N-(3,4-dichlorophenyl)-N-methylglycineHCID 57501273HCID 57501273, compound

Product 1

HCID 59809683HCID 59809683, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6228
Dimethylformamide
Solvent

Procedure

[1-(3-Bromophenyl)-2-(1-pyrrolidinyl)ethyl]methylamine (0.65 g, 2.30 mmol) was added to a solution of N-(3,4-dichlorophenyl)-N-methylglycine (0.65 g, 2.30 mmol), (benzotriazol-1-yloxy) tris(dimethylamino) phosphonium-hexaflurophosphate (BOP) (1.52 g, 3.40 mmol) and triethylamine (TEA) (0.70 g, 6.90 mmol) in N,N-dimethyl-formamide (DMF) (10 mL). The reaction mixture was stirred at RT for 12 h. Water (10 mL) was then added an the crude compound precipitated, was filtered and crystallized from ether and hexane to give the title compound as an off-white solid (0.62 g, 54%). MS (ES) m/e 499[M+H]+.

Workup

  1. customprecipitated
  2. filtrationwas filtered
  3. customcrystallized from ether and hexane

Sources & evidence

ORD record
ord-047573580d784aea88b794aef9806f67
Source dataset
uspto-grants-2008_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07432258B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes