Dimethyl Sulfoxide → 3-(4-(3-(1,1-Difluoroethyl)phenoxy)phenyl)pyridin-2-amine

HRID 211551

Reaction equation

HRID 211551 reaction equation
[Br:32][c:33]1[cH:34][c:35]([C:39]([CH3:40])([F:41])[F:42])[cH:36][cH:37][cH:38]1.[CH3:45][S:46]([CH3:47])=[O:48].[Cu:43][I:44].[K+:29].[K+:30].[K+:31].[NH2:10][c:11]1[n:12][cH:13][cH:14][cH:15][c:16]1-[c:17]1[cH:18][cH:19][c:20]([OH:23])[cH:21][cH:22]1.[OH:1][C:2]([c:3]1[n:4][cH:5][cH:6][cH:7][cH:8]1)=[O:9].[P:24]([O-:25])([O-:26])([O-:27])=[O:28]>>[NH2:10][c:11]1[n:12][cH:13][cH:14][cH:15][c:16]1-[c:17]1[cH:18][cH:19][c:20]([O:23][c:33]2[cH:34][c:35]([C:39]([CH3:40])([F:41])[F:42])[cH:36][cH:37][cH:38]2)[cH:21][cH:22]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation3×HCID 1018Picolinic acidHCID 1061PhosphateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 222401211-Bromo-3-(1,1-difluoroethyl)benzeneHCID 667484774-(2-Aminopyridin-3-yl)phenol

Product 1

HCID 667480523-(4-(3-(1,1-Difluoroethyl)phenoxy)phenyl)pyridin-2-amine

Sources & evidence

ORD record
ord-a85b5bb86741472bbf31dc9fa33419a5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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