Potassium Carbonate → 11-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate

HRID 2118993

Reaction equation

HRID 2118993 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.Cl[C:22]1[CH:23]=[C:24]([N:28]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[NH:30][C:29]2=[O:37])C=CC=1.[C:38]([O-])([O-:40])=[O:39].[K+].[K+]>CN(C=O)C>[C:29]([OH:37])(=[O:8])[C:38]([OH:40])=[O:39].[O:37]=[C:29]1[N:28]([CH2:24][CH2:23][CH2:22][N:1]2[CH2:2][CH2:3][CH:4]([CH:7]3[C:13]4=[CH:14][CH:15]=[CH:16][N:12]4[CH2:11][C:10]4[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=4[O:8]3)[CH2:5][CH2:6]2)[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[NH:30]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepineHCID 201916661-(3-Chlorophenyl)-benzimidazolin-2-one

Product 1

HCID 2019168511-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 50 ml dry DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g, 0.0186 mole), 1-(3-chlorophenyl)-1,3-dihydro-2H-benzimidazol-2-one (4.0 g 0.019 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

Sources & evidence

ORD record
ord-b956a76507984facbd2fd180d4fe610f
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Linked notes

Loading…