Tetrahydrofuran → tert-butyl 5-amino-2-[7-[[4-(chloromethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate
Reaction equation
[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[Cl:63][CH2:64][c:65]1[cH:66][cH:67][c:68]([CH2:71][OH:72])[cH:69][cH:70]1.[NH2:1][C:2]([CH2:3][CH2:4][CH:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[N:13]1[C:14](=[O:23])[c:15]2[cH:16][cH:17][cH:18][c:19]([OH:22])[c:20]2[CH2:21]1)=[O:24].[O:49]=[C:50]([O:51][CH:52]([CH3:53])[CH3:54])[N:55]=[N:56][C:57]([O:58][CH:59]([CH3:60])[CH3:61])=[O:62].[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[NH2:1][C:2]([CH2:3][CH2:4][CH:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[N:13]1[C:14](=[O:23])[c:15]2[cH:16][cH:17][cH:18][c:19]([O:22][CH2:71][c:68]3[cH:67][cH:66][c:65]([CH2:64][Cl:63])[cH:70][cH:69]3)[c:20]2[CH2:21]1)=[O:24]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-30d5f4dbb3ba4790956db46065bd1028
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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