Dimethylformamide → 6-[3-(2,4-Dichlorobenzylamino)-pyrrolidin-1-yl]-nicotinonitrile

Reaction equation

[CH:25]([N:26]([CH:27]([CH3:28])[CH3:29])[CH2:30][CH3:31])([CH3:32])[CH3:33].[Cl:16][c:17]1[n:18][cH:19][c:20]([C:21]#[N:22])[cH:23][cH:24]1.[Cl:1][c:2]1[c:3]([CH2:4][NH:5][CH:6]2[CH2:7][NH:8][CH2:9][CH2:10]2)[cH:11][cH:12][c:13]([Cl:15])[cH:14]1.[O:34]=[CH:35][N:36]([CH3:37])[CH3:38]>>[Cl:1][c:2]1[c:3]([CH2:4][NH:5][CH:6]2[CH2:7][N:8]([c:17]3[n:18][cH:19][c:20]([C:21]#[N:22])[cH:23][cH:24]3)[CH2:9][CH2:10]2)[cH:11][cH:12][c:13]([Cl:15])[cH:14]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 81531Diisopropylethylamine

HCID 51520946-Chloro-3-pyridinecarbonitrile

HCID 60137425N-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-amine

Product 1

HCID 598603496-[3-(2,4-Dichlorobenzylamino)-pyrrolidin-1-yl]-nicotinonitrile

Sources & evidence

ORD record: ord-669c6959ae154431be32616355a66201
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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